The present invention relates to iRNAs that target the complement factor B (CFB) gene, complement component C3 gene, and complement component C9 gene, such as double-stranded ribonucleic acid (dsRNA) compositions, and CFB, C9 and / or Or such an iRNA for treating a subject that inhibits the expression of C3 and is associated with a complement component related disease, such as paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome, for example It relates to a method of using a dsRNA composition.本発明は、補体Ｂ因子（ＣＦＢ）遺伝子、補体成分Ｃ３遺伝子、及び補体成分Ｃ９遺伝子を標的とするｉＲＮＡ、例えば、二本鎖リボ核酸（ｄｓＲＮＡ）組成物、及びＣＦＢ、Ｃ９及び／又はＣ３の発現を阻害し、補体成分に関連する疾病、例えば、発作性夜間血色素尿症及び非典型溶血性尿毒症症候群に罹患している対象を処置するためのこのようなｉＲＮＡ、例えば、ｄｓＲＮＡ組成物の使用方法に関する。
