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Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives
专利权人:
Ambrx; Inc.
发明人:
Miao, Zhenwal,Atkinson, Kyle C.,Biroc, Sandra,Buss, Timothy,Cook, Melissa,Kraynov, Vadim,Marsden, Robin,Pinkstaff, Jason,Skidmore, Lillian,Sun, Ying,Szydlik, Angieszka,Valenta, Ianina
申请号:
AU2020217337
公开号:
AU2020217337A1
申请日:
2020.08.11
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
#$%^&*AU2020217337A120200827.pdf#####ABSTRACT Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified posttranslationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology use.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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