Koji Kadowaki,Masaki Fujita,Yuka Sakaguchi,Kazuhiro Tanahashi
申请号：
US15562324
公开号：
US20180344906A1
申请日:
2016.03.31
申请国别(地区):
US
年份:
2018
代理人:
摘要：
An antithrombogenic metallic material includes a metallic material whose surface is coated with a coating material, the coating material containing: a phosphonic acid derivative or a catechol derivative； a polymer containing, as a constituent monomer, a compound selected from the group consisting of alkyleneimines, vinylamines, allylamines, lysine, protamine, and diallyldimethylammonium chloride； and an anionic compound containing a sulfur atom and having anticoagulant activity； the polymer being covalently bound to the phosphonic acid derivative or the catechol derivative, the phosphonic acid derivative or the catechol derivative being bound to the metallic material through a phosphonic acid group or a catechol group thereof, wherein the abundance ratio of nitrogen atoms to the abundance of total atoms as measured by X-ray photoelectron spectroscopy (XPS) on the surface is 4.0 to 13.0 atomic percent.
