The present invention relates to a device, particularly as or for a temperature adjustment infusion system, particularly for fever treatment and/or normothermia and/or hypothermia. The device comprises at least one reservoir suitable to provide infusion fluid at a temperature of between −1° C. and 14° C. at least one temperature sensor suitable to deliver at least one temperature signal at least one pump suitable to pump the infusion fluid in an average amount of between 100 ml and 8000 ml with an average flow rate of preferably 40 ml/h to 8000 ml/h at least a first outgoing duct for delivering the infusion fluid downstream from the reservoir at least one assembly controller. The assembly controller can be adapted to receive and compute the temperature signal from the temperature sensor to activate the pump if the temperature signal corresponds to at least a preset threshold temperature over a preset or given time so that the pump delivers infusion fluid in a preset or given amount to the first outgoing duct to thereafter stop the pump for a preset or given time to receive and compute the temperature signal after the preset or given time and repeat steps ii. and iii.
