GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED;INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE);INSTITUT JEAN PAOLI & IRENE CALMETTES;UNIVERSITE D'AIX-MARSEILLE;CENTRE NAT
The present invention relates to an ICOS binding protein or antigen binding portion thereof that is an agonist to human ICOS and does not induce complement, ADCC, or CDC when placed in contact with a T cell in vivo and methods of treating cancer, infectious disease and/or sepsis with said ICOS binding protein or antigen binding portion thereof. Further the ICOS binding proteins or antigen binding portions thereof of the present invention are capable of activating a T cell when placed in contact with said T cell； stimulating T cell proliferation when placed in contact with said T cell and/or inducing cytokine production when placed in contact with said T cell. The present invention relates to ICOS binding proteins or antigen binding portions thereof comprising one or more of: SEQ ID NO:1； SEQ ID NO:2； SEQ ID NO:3； SEQ ID NO:4； SEQ ID NO:5； and/or SEQ ID NO:6.本發明是有關於一種ICOS結合蛋白或其抗原結合部分，以及使用該ICOS結合蛋白或其抗原結合部分來治療癌症、傳染病及/或敗血病的方法，該ICOS結合蛋白或其抗原結合部分為人類ICOS的促效劑，但與T細胞在活體內接觸時不會誘發補體、ADCC或CDC。本發明ICOS結合蛋白或其抗原結合部分與T細胞接觸時進一步能活化T細胞；與該T細胞接觸時刺激T細胞增生及/或與該T細胞接觸時誘發細胞激素生成。本發明是有關於ICOS結合蛋白或其抗原結合部分，其包含下列中的一或多者：SEQ ID NO：1；SEQ ID NO：2；SEQ ID NO：3；SEQ ID NO：4；SEQ ID NO：5；及/或SEQ ID NO：6。
