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Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device
专利权人:
Rani Therapeutics; LLC
发明人:
IMRAN, Mir,ANSALONI, Sara,KORUPOLU, Radhika,HARRIS, Joel,HASHIM, Mir
申请号:
AU2018366110
公开号:
AU2018366110A1
申请日:
2018.11.07
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
Embodiments provide devices, preparations and methods for delivering therapeutic agents (TAs) such as clotting factors (CFs, e.g., Factor 8) within the GI tract. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations configured to be contained within the capsule, advanced from the capsule into the IW and/or surrounding tissue (ST) and degrade to release the TA into the bloodstream to produce a therapeutic effect (e.g., improved clotting). The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW or ST (e.g., the peritoneal cavity). Embodiments are particularly useful for delivery of CFs for treatment of clotting disorders (e.g., hemophilia) where such CFs are poorly absorbed and/or degraded within the GI tract.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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