Disclosed are granulocytes and their role in both cancer and inflammation. More particularly, it was found that c-Met expressed by granulocytes is important in transmigration and recruitment of the granulocytes. It is shown that reducing c-Met-mediated transmigration of granulocytes sustains tumor progression, indicating that c-Met-mediated granulocyte transmigration should actually be maintained because it is beneficial in treatment of cancers, particularly cancers that otherwise show resistance to c-Met inhibition. Reducing c-Met-mediated transmigration on the other hand is particularly useful in conditions characterized by an excessive immune response, such as asthma.
