Disclosed is an penta-specific antibody which has multiple specificity to (or cross reacts with) human IL-8, Gro-alpha, Gro-beta, Gro-gamma, and ENA-78. Also disclosed is the use of the penta-specific antibody in the preparation of a medicament for treating or preventing COPD, osteoarthritis, rheumatoid arthritis, erosive arthritis, asthma, atherosclerosis, inflammatory bowel disease, psoriasis, transplant rejection, gout, cancer, acute lung injury, acute lung disease, sepsis, ARDS, peripheral artery disease, systemic sclerosis, neonatal respiratory distress syndrome, exacerbation of asthma and COPD, cystic fibrosis, diffuse panbronchiolitis, reperfusion injury, and/or endometriosis.
