Jie Fu,Justin Hanes,Donald Jeffrey Zack,Zhiyong Yang,Derek Stuart Welsbie,Cynthia Ann Berlinicke
申请号：
US16692691
公开号：
US20200147044A1
申请日:
2019.11.22
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Methods for increasing the encapsulation or incorporation of Sunitinib into polymeric matrices have been developed. The resulting formulations provide for more sustained controlled release of sunitinib or other inhibitors of JNK signaling, which bind to DLK. Increased loading is achieved using an alkaline solvent system. The pharmaceutical compositions can be administered to treat or reduce neuronal death due to elevated intraocular pressure. Upon administration, the sunitinib or other inhibitor is released over an extended period of time at concentrations which are high enough to produce therapeutic benefit, but low enough to avoid unacceptable levels of cytotoxicity, and which provide much longer release than inhibitor without conjugate.
