A device for evaluation of a tissue's biological or biomechanical character is disclosed. The device uses negative pressure to draw a portion of the tissue across one or more electrode pairs disposed within the device. By measuring one or more parameters associated with an electric or magnetic field defined by the electrode pairs, in vivo evaluation of the tissue's biological or biomechanical character may be achieved in a minimally invasive manner. The device may also include an indenter to apply a positive stress on the tissue within the sidewall to further evaluate its biological or biomechanical character. A method of using the device is also disclosed.
