THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS;OCHSNER CLINIC FOUNDATION;NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
发明人:
Robert C. Gensure,Joshua Sakon,Osamu Matsushita,Tulasi Ponnapakkam
申请号：
US16517988
公开号：
US20190338010A1
申请日:
2019.07.22
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
