Methods and compositions for treating skin conditions are provided, including, for example, cellulite, cell death, and decreased blood flow. The present invention includes a stable topical formulation prepared by electrolyzing a saline solution to generate a target mixture of chemically reduced and oxidized molecules within the saline solution. The target mixture of chemically reduced and oxidized species may be mirrored to the reduced species and reactive oxygen species found in a known biological system by measuring concentrations of reactive oxygen species in the electrolyzed saline. A rheology modifier and buffering agent may be added. The formulation is applied to a skin area affected by one or more skin conditions.
