PROBLEM TO BE SOLVED: To provide a pharmacological composition for reducing metastasis of cancer in a patient who has a cancer characterized by an overexpression of a HER2 receptor protein, and who has failed a prior treatment using an anti-VEGF antibody.SOLUTION: This composition contains an anti-HER2 antibody. By this drug treatment, effective amounts of the anti-HER2 antibody as well as the anti-VEGF antibody can be administrated to the patient.【課題】HER2受容体タンパク質の過剰発現を特徴とする癌を有する患者であって、抗VEGF抗体を用いた事前の治療に失敗した患者の転移を低減するための医薬組成物の提供。【解決手段】本発明は、抗HER2抗体を含んで成る医薬組成物であって、有効な量の抗HER2抗体及び抗VEGF抗体が前記患者に投与される、医薬組成物を提供する。【選択図】図1