The present invention relates to a tissue regeneration membrane for repair and regeneration of peripheral nerve, which includes a collagen membrane and an anti-inflammatory medicinal composition dispersed therein uniformly, for wrapping an injured peripheral nerve. The collagen membrane protects the injured peripheral nerve from the infiltration of inflammatory cells, and the anti-inflammatory medicinal composition can inhibit neuroinflammation of the injured peripheral nerve, thereby promoting the repair and regeneration of the injured peripheral nerve.