The invention is to provide an ophthalmic lens comprising a lens body and an antimicrobial hydrophilic layer thereon and a manufacturing method thereof, wherein the antimicrobial hydrophilic layer comprises a polydopamine layer and a zwitterionic polymer non-covalently bonded on the polydopamine layer, and the zwitterionic polymer can be selected from one of the group consisting of phosphorylcholine polymer, sulfobetaine polymer, carboxybetaine polymer, mixed-charge polymer and a combination thereof.
