TYAVANAGIMATT, SHANTHAKUMAR R.,PAZ, JOSEPH,TAN, YING,HRUBY, DENNIS E.,SAMUEL, N K PETER
申请号：
CA2917199
公开号：
CA2917199A1
申请日:
2014.07.11
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2(1 H)-yl]-4-(trifluoromethyl)-benzamide for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus. Also disclosed are methods for the preparation of amorphous solid dispersion of N- [(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2(1 H)-yl]-4-(trifluoromethyl)-benzamide.
