Provide thieno [3,4-d] pyrimidin-7-yl and furans simultaneously [3,4-d] pyrimidin-7-yl nucleosides, nucleotide phosphate and its prodrug, and the intermediate and method of preparation. Compound, composition and the method for offer are suitable for treatment flaviviridae infections.提供了噻吩并[3,4-d]嘧啶-7-基和呋喃并[3,4-d]嘧啶-7-基核苷、核苷磷酸酯和其前藥,以及製備的中間體和方法。提供的化合物、組合物和方法適用於治療黃病毒科病毒感染。