RUBÉN LAGUENS,MARCELO L. ARGUELLES,GUSTAVO VERA JANAVEL,JOSÉ ALBERTO CROTTOGINI,CARLOS ALBERTO MELO,RICARDO HORACIA PICHEL,MARCELOS EDUARDO CRISCUOLO
申请号：
US14176616
公开号：
US20140341972A1
申请日:
2014.02.10
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates, e.g., to a method for inducing arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or for inducing mitosis or proliferation of a smooth muscle cell, a skeletal muscle cell, or a cardiomyocyte, comprising administering to a cell or tissue in need thereof a dose of a polynucleotide that encodes a vascular endothelial growth factor (VEGF), or that encodes a polypeptide comprising an active site of the VEGF. The coding sequence is operably linked to an expression control sequence and the dose is sufficient to induce arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or to induce mitosis or proliferation of a smooth muscle cell, a skeletal muscle cell, or a cardiomyocyte. In preferred embodiments of the invention, the method is a method of tissue regeneration, particularly of cardiomyogenesis and the polynucleotide (or a polypeptide encoded by such a polynucleotde) is administered into the myocardium.
