HUMANIZED ANTIBODIES THAT BIND LGR5

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专利权人:

发明人:

申请号：

EP15774211.5

公开号：

EP3126397A4

申请日:

2015.04.02

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

Disclosed herein is the methods that humanized anti-LGR5 antibody is used for treating cancer. Antibody as described herein does not interrupt LGR5-RSPO1 bindings or signaling in combination with LGR5, and may destroy LGR5 signalings and be independently of RSPO1 by wingless protein. This also disclosed in heavy chain and light chain polypeptide sequence faces LGR5, for example, without destroying LGR5-RSPO bindings or signaling.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/