SOLUBLE HER2 AND HER3 SPLICE VARIANT PROTEINS, SPLICE-SWITCHING OLIGONUCLEOTIDES, AND THEIR USE IN THE TREATMENT OF DISEASE

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专利权人:

Sarepta Therapeutics; Inc.

发明人:

KOLE, Ryszard,SAZANI, Peter,WAN, Jing

申请号：

EP08768187

公开号：

EP2173373A4

申请日:

2008.06.06

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

Soluble epidermal growth factor receptors 2 and 3 (HER2 and HER3) splice variant proteins with HER2 and HER3 antagonist activity and anti-proliferative properties, as well as the corresponding nucleic acids, are provided for treatment of proliferative diseases, in particular cancer. Also provided are compositions and methods for inducing expression of these splice variants, including splice switching oligonucleotides that modulate splicing of pre-mRNA that codes for these receptors.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/