Ho Sup YOON,Sreekanth RAJAN,Hui Ting TOH,Xuewei LIU,Hui YAO
申请号：
US16334550
公开号：
US20200038352A1
申请日:
2017.09.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Co-crystals comprising the Nuclear receptor related 1 protein-ligand binding domain (Nurr1-LBD) and a cyclopentenone prostaglandin are provided. Also provided are methods of identifying or designing Nurr1-modulating ligands and compounds based on the crystal structures described herein as well as the applications of said ligands and compounds as Nurr1 modulators or medicaments.
