JOHANNES OLDENBURG,CLEMENS R. MUELLER-REIBLE,TIM-MATTHIAS STROM,SIMONE ROST,ANDREAS FREGIN
申请号：
PT10002316
公开号：
PT2189523E
申请日:
2004.10.12
申请国别(地区):
PT
年份:
2012
代理人:
摘要：
The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying coumarin derivatives, and also claims VKORC1 polypeptides and VKORC1 nucleic acids containing a sequence abnormality associated with a VKORC1 associated deficiency such as warfarin resistance, wherein the VKORC1 polypeptides and VKORC1 nucleic acids can be used for diagnosing these deficiencies. Moreover, the invention relates to methods for identifying coumarin derivatives usable in pest control of rodents.
