The invention discloses a compound with the general formula of (I), wherein, K is selected from: naphthene alkyland haloalkane alkylor N—；R6. The invention also discloses a tyrosine kinase inhibitor containing the above compound and the application of the compound in preparing drugs for treating cancers. The tyrosine kinase inhibitor of the invention inhibits the bioactivity of multiple signal conduction kinases such as C-MET, VEGF, KDR, etc., it can effectively inhibit cell proliferation and has favorable therapeutic effects on various diseases such as cancer, it has significant therapeutic effects especially on lung cancer, gastric cancer, ovarian cancer, malignant glioma, etc., and it has a very broad application prospect.
