AFAR, DANIEL E. H.,HUBERT, RENE S.,RAITANO, ARTHUR B.,SAFFRAN, DOUGLAS C.,MITCHELL, STEVE CHAPPELL,FARIS, MARY,JAKOBOVITS, AYA
申请号：
CA2395053
公开号：
CA2395053C
申请日:
2000.12.06
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Described is a novel family of cell surface serpentine transmembrane antigens.Two of the proteins in this family are exclusively or predominantly expressedin the prostate, as well as in prostate cancer, and thus members of thisfamily have been termed "STEAP" (Six Transmembrane Epithelial Antigen of theProstate). Four particular human STEAPs are described and characterizedherein. The human STEAPs exhibit a high degree of structural conservationamong them but show no significant structural homology to any known humanproteins. The prototype member of the STEAP family, STEAP-1, appears to be atype IIIa membrane protein expressed predominantly in prostate cells in normalhuman tissues. Structurally, STEAP-1 is a 339 amino acid protein characterizedby a molecular topology of six transmembrane domains and intracellular N- andC- termini, suggesting that it folds in a "serpentine" manner into threeextracellular and two intracellular loops. STEAP-1 protein expression ismaintained at high levels across various stages of prostate cancer. Moreover,STEAP-1 is highly over-expressed in certain other human cancers.
