Sarat C. Chattaraj,Glenn Allen Redelman,Andrew Alan Shaw
申请号：
US14390556
公开号：
US09439860B2
申请日:
2012.10.23
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Various fenofibrate dosage forms contain a plurality of beads or particles, where the beads or particles include a pharmaceutical composition comprising fenofibrate from 0.3% to 10% by weight of the beads or particles of a surfactant and from about 5% to about 15% by weight of the beads or particles of a water soluble or water dispersible cellulosic binder. The mass ratio of the drug to the binder in the dosage form is between about 3.5:1 and 4.5:1 and the dosage form produces a first Cmax in vivo that is between about 10% and about 50% higher than a comparative Cmax produced by a comparative dosage form. The comparative dosage form comprises the drug and the binder in a ratio of between about 5:1 and 15:1.
