The present invention relates to compounds of formula (A1) or (A2) for use in the treatment of dehydrative peripheral neuropathy, and N-oxide derivatives or prodrugs thereof, or a pharmacologically acceptable salt, solvate or hydrate thereof . <； Formula (A1) >； [In the above formula, A is COOR 5 , OPO (OR 5 ) 2 , PO (OR 5 ) 2, SO 2 OR 5 , POR 5 OR 5 or 1H-tetrazol-5-yl wherein R 5 is H or an ester- 1-6 alkyl), and； W is a bond, C 1-3 alkylene or C 2-3 alkenylene； Y is a C 6-10 aryl or C 2-9 heteroaryl group (e.g., C 3-9 heteroaryl), and halogen, OH, NO 2, C 1-6 alkyl, C 1-6 alkoxy； Halo-substituted C 1-6 alkyl and halo-optionally substituted with 1 to 3 radicals selected from 6alkoxy-substituted C 1； Z is selected from the following formula (I)； (I) (Wherein the asterisk of Z has the formula Ia or formula Ib, each -C (R 3) (R 4 ) - , and represents the point of attachment between the A； R 6 is hydrogen and C 1- is selected from 6-alkyl； J 1 and J 2 are independently methylene, or S, O and NR 5 heteroatoms selected from and； wherein R 5 is hydrogen and C 1- is selected from 6 alkyl, any alkylene of Z are halo, hydroxy, C 1-6 may be further substituted by one to three radicals selected from alkyl or； or R 6 is attached to the carbon atom of Y may form a 5-to 7-membered ring)； R 1 is C 6-10 aryl or C 2-9 heteroaryl group (e.g., C 3-9 heteroaryl) and, C 1-6 alkyl, C 6-10 aryl, C 6-10 aryl C 1-4 alkyl, C 3-9 heteroaryl, C 3-9 heteroaryl, C 1-4 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl, C 1-4 alkyl, C 3-8 heterocycloalkyl or C 3- it is optionally substituted with alkyl 4-8 heterocycloalkyl C 1； Wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 1 is halogen, C 1-6 alkyl, C 1-6 alkoxy and halo-substituted -C 1-6 alkyl, -C 1-6 alkoxy group selected from <； / RTI >； R 2 is H, C 1-6 alkyl, halo-substituted C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl； R 3 and R 4 are each independently H, halogen, OH, C 1-6 alkyl, C 1-6 alkoxy or halo-substituted C 1-6
