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Method of treating proliferative disorders and other pathological conditions mediated by bcr-abl, c-kit, ddr1, ddr2 or pdgf-r kinase activity
专利权人:
NOVARTIS AG
发明人:
YIN OPHELIA,GALLAGHER NEIL
申请号:
NZ59996810
公开号:
NZ599968A
申请日:
2010.11.17
申请国别(地区):
NZ
年份:
2014
代理人:
摘要:
Disclosed is a regimen for the administration of a pyrimidyl-aminobenzamide of formula (I) wherein the radicals as defined herein, or of a pharmaceutically acceptable salt thereof, for the treatment of proliferative disorders, particularly solid and liquid tumours, and other pathological conditions mediated by the Bcr-Abl oncoprotein, the cell transmembrane tyrosine kinase receptor c-Kit, DDR1 (discoidin domain receptor 1), DDR2 (discoidin domain receptor 2) or PDGF-R (platelet derived growth factor receptor) kinase activity, wherein the pyrimidylaminobenzamide of formula I and, optionally, pharmaceutically acceptable carriers, are dispersed in a fruit preparation. The compound of formula (I) is preferably 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1 H-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide also known as nilotinib. The fruit preparation is preferably apple sause.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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