The present invention relates to compounds that may be useful in the treatment or prevention of SPT-related diseases, including congenital diseases with sphingolipid accumulation, including cancer and Niemann-Pick disease.本発明は、癌、ニーマンピック病を含むスフィンゴ脂質蓄積を伴う先天性疾患を含むSPT関連疾患の治療又は予防に有用であり得る化合物に関する。