Ka Ho Kenneth LEE,Ruohan CHEN,Zhibo HOU,Quanwei PAN
申请号：
US14680655
公开号：
US20150224106A1
申请日:
2015.04.07
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A method of treating a patient to improve liver functioning includes providing a drug composed of at least one of pharmaceutical 2-(4-morpholinoaniline)-6-cyclohexyl aminopurine and a salt thereof； and administering the drug to the patient in a manner and dosage effective to improve liver functioning. The 2-(4-morpholinoaniline)-6-cyclohexyl aminopurine can inhibit the activated hepatic stellate cells from synthesizing and expressing collagens and other extracellular matrix proteins including MMPs and TIMPs, and so it can inhibit liver fibrosis. In the liver, it can inhibit collagen synthesis and expression, and therefore reverse and treat hepatitis and liver cirrhosis effectively. Also disclosed is a method for preparing drugs for treating infective hepatitis, non-infectious hepatitis, liver injury, liver cirrhosis, liver cancer and liver fibrosis, and improving t liver functioning, in which the compound and/or salt thereof is used optionally or in combination with a target molecule or carrier comprising a vitamin A-coupled liposome.
