This invention is related to pharmacology, medicine, veterinary science and pharmaceutical industry； in particular to the process for the production of original composite antimicrobial and vulnerary preparations for external administration having an increased therapeutic efficiency in the treatment of skin and soft tissues infections. The claimed pharmaceutical composition contains antibiotic fosfomycin and finely dispersed nanostructured silica dioxide as active agents. The claimed process for the production of the pharmaceutical composition consists in mixing fosfomycin substance with finely dispersed nanostructured silica dioxide, characterized in that the micture of said substances in the weight ratio (25-75% by weight) : (75-25% by weight) respectively is being exposed to mechanical treatment by impact and abrasive actions to increase the weight percentage of the finely dispersed fraction (‰¤ 5 micron) to at least 40%.
