ROBERT DR. FRANK,GREGOR DR. BAHRENBERG,THOMAS DR. CHRISTOPH,BERNHARD DR. LESCH,JEEWOO PROF. DR. LEE
申请号：
ARP120103517
公开号：
AR088002A1
申请日:
2012.09.25
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Pharmaceutical compositions containing these Compounds, and these compounds for use in the prophylaxis and / or treatment of Pain and Disease and / or additional disorders.Claim 1: substituted Compound of General formula (1) wherein one of the waste r u00b9 and R u00b2 means ch u2082 - N (r u2077) - S (= o) - r u2078 u2082, where r u2077 represents h, ch u2083 or c u2082h u2085, and where r u2078 represents nh u2082, ch u2083 or c u2082h u2085 respective, and the remaining residue r u00b9 and R u00b2 Selection To the group consisting of H, F, CL, BR, I, ch u2083, ch u2082 ch u2082 ch u2082 - - - Oh, Oh, ch u2082 ch u2083 - or - - - - - ch u2082 ch u2082 or ch u2083, cf u2083, Oh, or - or - ch u2082 ch u2083, - Oh,Ch u2082 ch u2083 - or - or - or - or - c u2082h u2085, ch u2082 ch u2082 - Oh -, - or - ch u2082 ch u2082 - or - ch u2083 and nh u2082； r u00b3 is selected from the group consisting of H, F, CL, BR, I, ch u2083, cf u2083, Oh, ch u2083 or - or - cf u2083 and nh u2082； Z is n or C - r u2074 u1d47, where r u2074 u1d47 represents H or ch u2083； r u2074 u1d43 represents H or ch u2083； r u2075 represents H OR Ch u2083； X is n or CH； r u2076 represents cf u2083, an aliphatic residue 1 to 4 carbon ATOMS, saturatedNot replaced or residue cicloalif u00e1tico 3 to 6 carbon Atoms are saturated, not replaced； a u00b9 represents N or cr u2079 a-squared represents or cr u00b9 u2070； n； n represents A u00b3 or cr u00b9 u00b9； a u2074 represents N or cr u00b9 u00b2； a u2075 represents N or cr u00b9 u00b3； under the condition of 0, 1, 2 or 3 of the variables a u00b9 a-squared,, - a u2074 and a u2075 represents a nitrogen Atom； and r u2079, r u00b9 u2070, r u00b9 u00b9, r u00b9 u00b2 and r u00b9 u00b3 each independently represent h,F, CL, BR, I, CN, no u2082, cf u2083, cf u2082h, cfh u2082, Oh, ocf u2083, nh u2082； an aliphatic residue 1 to 4 carbon ATOMS, an aliphatic residue or - 1 to 4 carbon ATOMS, an aliphatic residue NH - 1 to 4 carbon Atoms and the N (aliphatic res
