PURDUE RESEARCH FOUNDATION;NIELSEN, JEFFERY JAY HOWARD;LOW, PHILIP S.;LOW, STEWART ANDREW;NIELSEN, JEFFREY JAY HOWARD
发明人:
LOW, PHILIP S.,LOW, STEWART ANDREW,NIELSEN, JEFFERY JAY HOWARD,NIELSEN, JEFFREY,NIELSEN, JEFFREY JAY HOWARD
申请号：
CA3045458
公开号：
CA3045458A1
申请日:
2017.11.30
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Disclosed herein includes a drug delivery system comprising at least one peptide and a targeting ligand for bone fracture and/or for bone healing. Some embodiments include a peptide delivery system comprising at least an acidic, basic, hydrophilic, hydrohobic or neutral peptide linked to an acidic peptide or nonpeptidic polyanion for use in targeting the aforementioned attached peptide to a bone fracture surface. In some embodiments, a conjugated peptide expresses an anabolic function that acts through PTH receptor 1, and various formats of targeting ligands guide the drug to raw hydroxyapatite. This system offsets some side effects caused by free anabolic drug, such as high blood calcium concentration
