#$%^&*AU2011203203B220140410.pdf#####ABSTRACT A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally； a first polymeric adhesive matrix, 5 in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug； a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile； and a release liner in contact with the second polymeric adhesive 10 matrix. The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled. 15 document2l1/2 Figure 1: Transdermal Flux (Rate of Delivery) -- Slow Delivery Matrix Rapid Delivery Matrix - - Bi-Layer (80% rapid matrix, 20% slow matriv E Time d)I 0I
