Mohammad S. Hossain;John D. Roback;Edmund K. Waller;Andrew T. Gewitz
发明人:
Mohammad S. Hossain,Andrew T. Gewitz,John D. Roback,Edmund K. Waller
申请号：
US13121016
公开号：
US08486408B2
申请日:
2009.10.02
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Methods are disclosed for treating or preventing graft versus host disease in a subject. The methods include selecting a subject in need of treatment for graft versus host disease； and administering to the subject a therapeutically effective amount of a TLR5 agonist such as a flagellin polypeptide, or a polynucleotide encoding the flagellin, thereby treating or preventing graft versus host disease in the subject. Methods are also disclosed for reducing susceptibility to an opportunistic infection in a subject who is a bone marrow transplant recipient. The methods include selecting a subject who has had a bone marrow or hematopoietic stem cell transplant； and administering to the subject a therapeutically effective amount of a TLR5 agonist such as a flagellin polypeptide or a polynucleotide encoding the polypeptide, and administering to the subject an effective amount antigen of the opportunistic infection, thereby reducing the susceptibility to the opportunistic infection in the subject.
