DOW, ROBERT LEE,MORGAN, BRADLEY PAUL,SWICK, ANDREW GORDON,LIU, KEVIN KUN-CHIN,DOW, Robert Lee,MORGAN, Bradley Paul,SWICK, Andrew Gordon,LIU, Kevin Kun-Chin
申请号：
YUP76001
公开号：
RS52134B
申请日:
2000.03.27
申请国别(地区):
YU
年份:
2012
代理人:
摘要：
The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides intermediates and processes for preparing these compounds.Jedinjenje formule IInjegov izomer ili farmaceutski prihvatljiva so jedinjenja ili izomera； pri čemu je R1 a) -(C2-C4)alkil, b) -CH2-CH=CH2 ili c) -fenil； R2 je -OH；R3 je a) -(C1-C6)alkil supstituisan sa 0 ili 1 CF3, b) -OC-CH3, c) -C=C-C1, d) -OC-CF3, e) -CH2O(C1-C3)alkil supstituisan sa 0 ili 1 CF3 ili f) -CF3；R10 je -C(O)-NH-Z-het pri čemu je het izabran iz grupe koja se sastoji od a) piridinila supstituisanog sa 0 ili 1 metil grupom, b) pirimidinila, c) pirazinila, d) morfolinila i e) oksadizazolila；Z je-(C0-C2)alkil.Prijava sadrži još 10 patentnih zahteva.
