ДЖОЗЕФ Александра (US),РИЧАРДС Сьюзан (US),РУЗЕК Мелани (US),ГАРМАН Ричард (US)
申请号：
RU2013155618/15
公开号：
RU2013155618A
申请日:
2012.05.03
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A method of increasing the effectiveness of a therapeutic agent in a subject in need of treatment with a therapeutic agent, comprising administering to the subject an effective amount of methotrexate, thereby increasing the effectiveness of the therapeutic agent in the subject. The method of claim 1, wherein the effective amount of methotrexate is administered in a single cycle. The method according to claim 1 or 2, which includes: a. the induction of immunological tolerance to a therapeutic agent in a subject； b. inhibition of antibody formation against a therapeutic agent in a subject c. facilitating an infusion response to a therapeutic protein in a subject； d. attenuation of secondary autoimmunity in a subject e. an increase in the percentage of regulatory T cells in a T cell population in a subject f. an increase in the percentage of regulatory B cells in a B cell population in a subject； or g. inhibition of T cell responses in a subject. 4. The method according to claim 1 or 2, in which the subject is a person. The method according to claim 4, wherein the subject is a patient with multiple sclerosis, a patient who needs tissue transplantation, a patient who needs organ transplantation, a patient suffering from aplastic anemia, or a patient who has or is at risk of having a homologous disease. A method according to claim 1 or 2, wherein the therapeutic agent is a therapeutic protein. The method of claim 6, wherein the therapeutic agent is a therapeutic antibody. The method of claim 7, wherein the therapeutic antibody is a lymphocyte-depleting agent. The method of claim 6, wherein the therapeutic agent is an enzyme. The method of claim 9, wherein the enzyme is alpha ga1. Способ увеличения эффективности терапевтического средства у субъекта, нуждающегося в лечении терапевтическим средством, включающий введение субъекту эффективного количества метотрексата, тем самым увеличивая эффективность терапевтического средства у субъекта.2. Способ по п. 1, в котором эффек
