НАВРОЦКИ Стефан Т. (US),КЭРЬЮ Дженнифер С. (US),РЕДДИ Гуру (US)
申请号：
RU2012135396/15
公开号：
RU2012135396A
申请日:
2011.03.08
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A method for treating cancer comprising: a) administering to a mammal in need thereof an effective amount of an autophagy inhibitor based on thioxanthone and b) administering to a mammal in need thereof an effective amount of a caller autophagy compounds for treating cancer, wherein the administration as an autophagy inhibitor based on thioxanthone and causing autophagy compounds for treating cancer reduces a symptom associated with cancer, ensuring thereby treating cancer. 2. The method of claim 1, wherein the autophagy inhibitor based on thioxanthone represents 1 - ((2- (diethylamino) ethyl) amino) -4-methylthioxanthen-9-one, 1- (2-diethylaminoethylamino) -4- ( hydroxymethyl) -9-thioxanthenone, N - [[1 - [[2- (diethylamino) ethyl] amino] -9-oxo-9H-tiaksanten-4-yl] methyl] methanesulfonamide, its analogues or indazole soli.3. A method according to claim 1, characterized in that the calling autophagy compound for the treatment of cancer is arsenic trioxide, etoposide, rapamycin, histone deacetylase inhibitor, tyrosine kinase inhibitors, tamoxifen, temozolomide, or imatinib bortezomib.4. A method according to claim 3, wherein the histone deacetylase inhibitor is a histone deacetylase inhibitor hydroxamated type or histone deacetylase inhibitor tipa.5 benzamide. A method according to claim 3, wherein the histone deacetylase inhibitor is (2E, 4E, 6R) -7- (4-dimethylaminophenyl) -N-hydroxy-4,6-dimethyl-7-oxoheptyl 2,4-dienamide, N-hydroxy-N-feniloktandiamid, 4-dimethylamino-N- (6-gidroksikarbamoilgeksil) benzamide, N-hydroxy-3 - [(E) -3- (hydroxyamino) -3-oxoprop-1-enyl] -benzamide (2E) -3- [3- (anilinosulfonil) phenyl] -N-gidroksiakrilamid, ((E) -N-hydroxy-3- [4 - [[2-hydroxyethyl- [2- (1H-indol-3-yl ) e1. Способ лечения рака, включающий:a) введение млекопитающему, нуждающемуся в этом, эффективного количества ингибитора аутофагии на основе тиоксантона иb) введение млекопитающему, нуждающемуся в этом, эффективного количества вызывающего аутофагию соединения для лечен
