The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions； (b) an extracellular spacer domain； (c) a transmembrane domain； (d) at least one co-stimulatory domain； and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.
