The invention relates to the hydrocortisone derivative of formula (I), whose IUPAC name is 3-[3,5-Dihydroxy-3-(2-hydroxy-acetyl)-3a,6-dimethyl-7-oxo-dodecahydro-cyclo- penta[alpha]naphthalen-6-yl]-propionic acid, designated as Deina®, for use in the treatment of atrophic tissues, particularly skin, cartilage, connective, and mucosal tissues and scalp skin. formula (I)