The present invention provides chimeric compounds that modulate protein function, to restore protein homeostasis, including cytokine, aiolos, and/or ikaros activity, TNF-alpha activity, CK1-alpha activity and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of protein-mediated diseases, disorders, and conditions are provided.本發明提供調節蛋白質功能之嵌合化合物以恢復蛋白質穩態(包括細胞介素、艾俄洛斯(aiolos)及/或伊卡洛斯(ikaros)活性、TNF-α活性、CK1-α活性及細胞-細胞黏附)。本發明提供調節蛋白質介導之疾病(諸如細胞介素介導之疾病、失調症、病症或反應)之方法。本發明提供包括與其他細胞介素及發炎介質組合之組合物。本文提供治療、改善或預防蛋白質介導之疾病、失調症及病症之方法。
