Pharmaceutically acceptable compounds and salts of the compounds are described. Pharmaceutical compositions, treatment methods, synthetic methods, and synthetic intermediates are also described. Claim 1: A compound having the absolute stereochemistry according to formula (1) wherein R¹ is hydrogen, C₁₋₆ alkyl,alquenilo C o - (C (R R)) - (cicloalquilo C)In this case, the adhesive, adhesive or cyclopropyl ion can be replaced independently with 1-3r8310；R² is halogen, hydrogen, C₁₋₆ alkyl,alquenilo C o - (C (R R)) - (cicloalquilo C)In this case, the adhesive, adhesive or cyclopropyl ion can be replaced independently with 1-3r8310；R³ᵃ is hydrogen, C₁₋₆ alkyl,C₂₋₆ alkenyl,- (C (R R)) - (cicloalquilo C)-(c) (r8309； r74919； r8309； (749595))； 8344； - (4-10-member unorthodox Technology)；- (C (R R)) - (arilo C)-(C (r8309；)； 74919； (r8309；)； 749544； - (5-10-unorthodox member)- (C (R R)) -OR-C (O) N (R)- (C (R R)) -NHC (O) R o - (C (R R)) -N (R)In this case, the asphalt, tonsil, cyclopropyl or isocyclopropyl can be replaced independently with 1-3r83044.(a) In one case, arilo or heterosexual parts can be replaced by one to five r1830404；R³ᵇ is hydrogen, C₁₋₃ alkyl,- (C (R R)) - (cicloalquilo C)-(C (r8309；)； r8309；； 749595)； 8344； - (4-A 5-member non Biochemistry) or - (C (r8309；)； 7491；； r8309；； 749544； - or 8311811)；In these places, the asphalt, cyclopropyl or non cyclopropyl parts can be replaced independently with 1-3 r83044；R8308；]-CN or -OR⁹；a. On the basis of substitution, we use one to three fluorinated tar； r8308； 74955 and r8308； 74969 is fluorine, chlorine, hydrogen, tar c83218331；-CN O-OR1；Use of pitch from one to three fluorides on an alternative basis； or r8308；； 758080 and r8308； - 74966；In addition to the linked carbon, they form a 5-6-member cyclododecane or a 6-member arilo, in which the cyclododecane or arilo can optionally be replaced by 1-3-cf8323；fluorine, C₁₋₆-alkyl,-O-alkyl C₁₋₆,-OH, -NH₂ or -NH-C₁₋₆-alkyl；R8308；]-CN O-OR1；Use of carbon I to trifluoride on
