用於作為SHP2抑制劑之新穎雜環衍生物农业专利-农业专业知识服务系统

发明人:: MA, CUNBO,马存波,馬存波,GAO, PANLIANG,高攀亮,HU, SHAOJING,胡　邵京,XU, ZILONG,徐子龙,徐子龍,HAN, HUIFENG,韩慧峰,韓慧峰,WU, XINPING,吴新平,吳新平,KANG, DI,康迪,LONG, WEI,龙伟,龍偉,胡邵京

摘要：: The invention relates to a novel pyrazine derivative (which is shown as Formula I) as a SHP2 inhibitor, its synthesis method and its use for treating, inhibiting or preventing a disease or disorder mediated by the activity of SHP2. More particularly, the invention relates to a fused heterocyclic derivative useful as inhibitors of SHP2, methods for producing such compounds and methods for treating, inhibiting or preventing a disease or disorder mediated by the activity of SHP2.本發明關於可用作SHP2抑制劑的新穎吡衍生物(如結構式I所示)，及其合成方法及治療、阻止或預防由SHP2活性媒介的疾病或失調。進一步，本發明關於用於作為SHP2抑制劑的融合雜環衍生物，及製備該化合物的方法及治療、阻止或預防由SHP2活性媒介的疾病或不適的方法。