A system for adjusting the temperature of a patient, comprising a primary fluid circuit including a primary fluid circuit pump, a primary fluid heat exchanger, and primary fluid circuit lines connecting the primary fluid circuit pump to the primary fluid heat exchanger. A secondary fluid circuit is also provided together with a heat exchange catheter insertable into a patient. A cassette having a secondary heat exchanger with a primary side having releasable couplers for releasably connecting to the primary fluid circuit that fluidly seal when not connected to the primary fluid circuit. A secondary fluid circuit pump flows a secondary heat exchange fluid through a secondary fluid circuit to the heat exchange catheter and back through the secondary fluid circuit to the secondary fluid circuit reservoir. The cassette is configured for insertion into a housing in which is disposed a secondary fluid circuit pump motor, and is also configured to be removably received by the housing such that the secondary fluid circuit pump releasably engages the secondary fluid circuit pump motor.
