#$%^&*AU2012216435A120120913.pdf#####ABSTRACT OF THE INVENTION A compound having the general structure shown in Formula I: R R2 Ar2 R4,N )n 5 Ar 0 R (I) or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example 10 various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.