REID M. RUBSAMEN,CHARLES VINCENT TAYLOR HERST,DAVID EARL HECKERMAN
申请号：
US13826804
公开号：
US20140105970A1
申请日:
2013.03.14
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A composition as disclosed is comprised of a plurality of particles and a pharmaceutically acceptable carrier. The particles are comprised of (1) an adjuvant； (2) a biocompatible polymer which maybe a co-polymer such as PLGA, and (3) a peptide of a sequence of interest, e.g. a sequence which corresponds to a sequence presented on a surface of a cell infected with a virus. The carrier includes an adjuvant such as a monophosphoryl lipid A (MPL) different from the adjuvant in the particles. The particles may be sized such that they are sufficiently large so as to prevent more than the contents of a single particle from being presented to a single immune system cell.
