INHIBITEURS A PETITES MOLECULES DE SPHINGOMYELINASE 2 NEUTRE (NSMASE2) POUR TRAITER DES MALADIES NEURODEGENERATIVES

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专利权人:

INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY AS CR V.V.I.;THE JOHNS HOPKINS UNIVERSITY

发明人:

SLUSHER, BARBARA,ROJAS, CAMILO,THOMAS, AJIT G,NENCKA, RADIM,SALA, MICHAL,HREBABECKY, HUBERT

申请号：

CA3049428

公开号：

CA3049428A1

申请日:

2018.01.05

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) and their use for treating neurodegenerative diseases, such as, neurodegenerative diseases associated with high levels of ceramide, including, but not limited to Alzheimer's disease (AD), HIV-associated neurocognitive disorder (HAND), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), and, in other aspects, for treating cancer, are provided.

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http://www.ckcest.cn/home/