Kathrin Tissot,Stefan Ewert,Adrian Auf Der Maur,Alcide Barberis,Dominik Escher
申请号：
US16175002
公开号：
US10570190B2
申请日:
2018.10.30
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Compositions are provided, which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. These frameworks have been selected for intracellular performance and are thus ideally suited for the creation of scFv antibody fragments or scFv antibody libraries for applications where stability and solubility are limiting factors for the performance of antibody fragments, such as in the reducing environment of a cell. Such frameworks can also be used to identify highly conserved residues and consensus sequences which demonstrate enhanced solubility and stability.
