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ANTI-CANCER VACCINE PRODUCT CONTAINING WT1 PEPTIDE IN THE FORM OF TRANSDERMAL INTRODUCTION TAPE
专利权人:
ОСАКА ЮНИВЕРСИТИ (JP);НИТТО ДЕНКО КОРПОРЕЙШН (JP)
发明人:
МАЕДА Йосики (JP),ОКУБО Кацуюки (JP),АСАРИ Дайсуке (JP),ОКАДЗАКИ Аримити (JP),СИСИДО Такуя (JP),ХОРИ Мицухико (JP),СУГИЯМА Харуо (JP)
申请号:
RU2014102937/10
公开号:
RU2014102937A
申请日:
2014.01.29
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
An anticancer vaccine preparation in the form of a tape for use in the induction of cellular immunity, comprising: a substrate and an adhesive layer comprising an adhesive placed on one side of the substrate, where the adhesive layer carries a combination of: (i) a WT1 peptide and / or a modified WT1 peptide; and (ii) a first stimulator of the induction of cellular immunity selected from a TLR ligand, a cyclic dinucleotide, a helper peptide, an immunomodulating low molecular weight drug, a cyclooxygenase inhibitor, a prostaglandin receptor antagonist, a prostaglandin receptor agonist, a TSLP agonist inhibitor, an acid inhibitor of 3, an acid inhibitor of 3, an inhibitor of 3 fatty acid acid inhibitor PPAR agonist, dopamine receptor antagonist, dopamine receptor agonist, histamine receptor agonist, histamine receptor antagonist, seroton receptor agonist on, a serotonin receptor antagonist, a vasopressin receptor antagonist, a vasopressin receptor agonist, a muscarinic receptor antagonist, a muscarinic receptor agonist, an adrenaline receptor antagonist, an adrenaline receptor agonist, an angiotensin receptor agonist, an agonist agonist receptor agonist, an agonist agonist ADP receptor agonist, leukotriene receptor antagonist, leukotriene receptor agonist, melatonin receptor agonist, receptor agonist somatostatin, cannabinoid receptor agonist, sphingosine 1-phosphate receptor agonist, glutamate metabotropic receptor agonist, phospholipase A2 inhibitor, TGF-β production inhibitor, Th2 cytokine inhibitor, and a combination of two or more of these species; where1. Препарат противораковой вакцины в форме ленты для применения в индукции клеточного иммунитета, содержащий:подложку иадгезивный слой, содержащий адгезив, размещенный на одной стороне подложки, где адгезивный слой несет комбинацию:(i) пептида WT1 и/или модифицированного пептида WT1; и(ii) первого стимулятора индукции клеточного иммунитета, выбранного из лиганда TLR, циклического динуклеотида, хелперного пептида,
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