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НОВЫЕ ИНЪЕКЦИОННЫЕ КОМПОЗИЦИИ ЭПРИНОМЕКТИНА
专利权人:
СЕВА САНТЕ АНИМАЛЕ СА (FR)
发明人:
СИЙЕ Аннель (ZA)
申请号:
RU2013103140/15
公开号:
RU2013103140A
申请日:
2011.06.29
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. Injectable veterinary parasiticidal formulation comprising a therapeutically effective amount of a macrocyclic lactone slabolipofilnogo and a solvent system comprising polyethylene glycol, optionally together with other solvents and napolnitelyami.2. Composition according to Claim. 1, wherein the macrocyclic lactone is the distribution coefficient or log P of less than about 5, or from about 4 to about 5, or about 4.5, or about 4,4.3. Composition according to Claim. 1, wherein the macrocyclic lactone is eprinomektin.4. Composition according to Claim. 1 comprising at least about 20% PEG for vesu.5. A composition according to claim. 4, comprising from 20 to 98% PEG by weight or from 40 to 95% PEG by vesu.6. A composition according to claim. 4 or 5, comprising about 93% PEG for vesu.7. Composition according to Claim. 1 wherein the solvent system further comprises a combination of benzyl alcohol and N-metilpirrolidona.8. Composition according to Claim. 1 further comprising a pharmaceutically acceptable medium selected from the group consisting of propylene glycol, formalglitserin, isosorbide dimethyl ether, ethanol, dimethyl sulfoxide, tetrahydrofurfuryl alcohol, triacetin, and sochetaniya.9. Composition according to Claim. 1 wherein the solvent system is present in an amount sufficient to achieve a lasting effect, bioavailability and eprinomektina.10. Composition according to Claim. 1, comprising from about 0.5% to about 5% eprinomectin, from about 0.5% to about 5% of benzyl alcohol, from about 0.5% to about 5% N-methylpyrrolidone and made up in polyethylene glycol. eleven. Composition according to claim. 10 containing eprinomectin approximately 1%, approximately 1% of benzyl1. Инъекционная паразитицидная ветеринарная композиция, содержащая терапевтически эффективное количество слаболипофильного макроциклического лактона и систему растворителей, содержащую полиэтиленгликоль, необязательно вместе с другими растворителями и наполнителями.2. Композиция по п. 1, где мак
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