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COMPOSITIONS INCLUDING A CHOLINESTERASE INHIBITOR FOR THE TREATMENT OF COGNITIVE DISORDERS
专利权人:
Инк. (US);Аллерган
发明人:
СТАУБЛИ Урсула В. (US),ДОНЕЛЛО Джон Е. (US)
申请号:
RU2012103401/15
公开号:
RU2012103401A
申请日:
2010.07.16
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A pharmaceutical composition comprising a pharmaceutically effective cholinesterase inhibitor and a compound of Formula I: wherein X is CH or CH-CH, A is aryl or heteroaryl with 0, 1, 2 or 3 heteroatoms selected from the group consisting of N, S and O wherein A contains 0, 1, 2 or 3 substituents, each of which includes from 0 to 8 carbon atoms, from 0 to 3 oxygen atoms, from 0 to 3 halogen atoms, from 0 to 2 nitrogen atoms, from 0 to 2 sulfur atoms and from 0 to 24 hydrogen atoms. 2. The pharmaceutical composition according to claim 1, characterized in that A is selected from the group consisting of pyridinyl, thienyl, furyl, quinolinyl, methylphenyl and biphenyl. The pharmaceutical composition according to claim 1, characterized in that the compound of Formula I is selected from the group consisting of ,,,,,,,, as well as enantiomers and their pharmaceutically acceptable salts. The pharmaceutical composition according to any one of claims 1 to 3, characterized in that the cholinesterase inhibitor is selected from the group consisting of donepezil, galantamine and rivastigmine. A method for treating a cognitive disorder comprising administering to a person in need of such treatment a pharmaceutical composition comprising a pharmaceutically effective cholinesterase inhibitor and a compound of Formula I: wherein X is CH or CH — CH, A is aryl or heteroaryl with 0, 1, 2 or 3 heteroatoms selected from the group consisting of N, S and O, wherein A contains 0, 1, 2 or 3 substituents, each of which contains from 0 to 8 carbon atoms, from 0 to 3 oxygen atoms, from 0 to 3 halogen atoms , from 0 to 2 nitrogen atoms, from 0 to 2 sulfur atoms and from 0 d 24 vodoroda.6 atoms. The method according to claim 5, characterized in that A is selected from the group consisting of pyridinyl, thienyl, furyl, quinol�1. Фармацевтическая композиция, включающая фармацевтически эффективный ингибитор холинэстеразы и соединение по Формуле I:где Х является СНили CH-CH,А является арилом или гет
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来源网址:
http://www.ckcest.cn/home/
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